Resource Studies

Have questions about testosterone treatment or medical weightloss? Please check out the resources below to help answer all your questions.

TRT and Sexual Function - Endocrinological Control

~ The Journal of Sexual Medicine, ScienceDirect

Testosterone and Erectile Dysfunction
Testosterone and Erectile Dysfunction

Aging is associated with a decline in several important health factors in men, including libido. Serum testosterone concentrations also decrease with age, and many age-related clinical features are closely associated with androgen deficiency, including erectile function (ED). Approximately 70% of ED...

~ PubMed

Andropause: Introducing the Concept of ‘Relative Hypogonadism’ in Aging Males
Andropause: Introducing the Concept of ‘Relative Hypogonadism’ in Aging Males

Andropause affects many organ systems including the brain, heart, bones, muscle, adipose tissue, and blood vessels besides the sexual organs. The authors state that the prevalence of hypogonadism in aging males is not well established. There are many epidemiological studies that point towards a decl...

~ PubMed

Testosterone and Weight Loss: The Evidence

~ National Library of Medicine

What Is a Normal Testosterone Level for Young Men?
What Is a Normal Testosterone Level for Young Men?

Rethinking the 300 ng/dL Cutoff for Testosterone Deficiency in Men 20-44 Years Old

~ PubMed

Testosterone Eliminates Negative Choices in Men
Testosterone Eliminates Negative Choices in Men

Testosterone eliminates strategic prosocial behavior through impacting choice consistency in healthy males - A study by Nature.

~ Nature

Evaluation and Management of Testosterone Deficiency: AUA Guideline
Evaluation and Management of Testosterone Deficiency: AUA Guideline

This is the American Urological Association’s Guideline for diagnosis and treatment of low testosterone.  

~ PubMed

TRT & Heart Health
TRT & Heart Health

This meta-analysis demonstrates a reduced cardiovascular risk with higher endogenous T concentration, improvement of known cardiovascular risk factors with TRT therapy, and reduced mortality in testosterone deficient men who underwent TRT replacement therapy versus untreated men. TRT improves myocar...

~ PubMed

TRT and Prostate Cancer
TRT and Prostate Cancer

Evidence suggests that testosterone replacement therapy does not support an increased risk.  This meta-analysis of TRT and prostate risk demonstrates a short-term increase in PSA and prostate volume.  However, there was no increased risk of prostate cancer or prostate-related events in patients on t...

~ PubMed

Cardiovascular Disease, Hypogonadism and ED: Early Detection, Prevention and the Positive Effects of Long-Term TRT
Cardiovascular Disease, Hypogonadism and ED: Early Detection, Prevention and the Positive Effects of Long-Term TRT

In this prospective longitudinal study of 622 men on TRT: erectile function increased significantly, average weight loss was 23.6 ± 0.6 kg after 8 years, blood glucose readings improved and several patients with diabetes went into remission.  Cholesterol levels improved significantly and systolic bl...

~ National Library of Medicine

DEA Telemedicine Compliance
DEA Telemedicine Compliance

How does Telemedicine compliance current work with the live rules, laws, and regulations evolving in healthcare today?

~ AlphaMD

Viagra Lowers the Risk of Alzheimer’s by Almost 70%, Study Finds
Viagra Lowers the Risk of Alzheimer’s by Almost 70%, Study Finds

Viagra Lowers the Risk of Alzheimer’s by Almost 70%, Study Finds

~ National Institutes of Health

TRT and Mortality in Older Men
TRT and Mortality in Older Men

This review demonstrates there are benefits to treating older men with TRT to improve sexual function, increase lean muscle mass and strength, improve mood and cognitive function, and reduce frailty and osteoporosis. This article confirms that there is no evidence that TRT is associated with increas...

~ PubMed

Cardiovascular Benefits and Risks of TRT in Older Men with Low T
Cardiovascular Benefits and Risks of TRT in Older Men with Low T

This meta-analysis of 58 research papers regarding TRT and heart health demonstrates that TRT is safe and is associated with prevention of CVD and strokes in hypogonadal men. These studies have have also demonstrated that normal T levels or the normalization of low T levels with testosterone replace...

~ PubMed

Testosterone vs Clomiphene Citrate
Testosterone vs Clomiphene Citrate

This study compared traditional TRT with testosterone injections vs. alternative therapy with clomiphene to raise testosterone.  This study showed men treated with TRT showed significant increases in libido, erectile function, and sports performance over men taking clomiphene. Among the men who rece...

~ PubMed

Alternatives to Testosterone Replacement: Testosterone Restoration
Alternatives to Testosterone Replacement: Testosterone Restoration

The European Male Aging Study has demonstrated that the hypogonadism of male aging is predominantly secondary. Theoretically with appropriate stimulation from the pituitary, the aging testis should be able to produce eugonadal levels of testosterone. The strategies for the treatment of late onset hy...

~ PubMed

Testosterone in Men with Hypogonadism and Transgender Males
Testosterone in Men with Hypogonadism and Transgender Males

This review article compared different formulations of testosterone; gels, patches, and injection with different esters.  It found that patient satisfaction seems to be in favor of long-acting i.m. injections due to the low injection frequency with stable testosterone levels and no daily confrontati...

~ PubMed

Elevated Hematocrit (erythrocytosis)
Elevated Hematocrit (erythrocytosis)

The most frequently reported adverse reaction to testosterone replacement therapy is erythrocytosis, an abnormal elevation of hemoglobin (greater than 18.5 g/dL) or hematocrit (greater than 52%).  However, no studies to date have demonstrated a link between testosterone replacement therapy-induced e...

~ PubMed

TRT and Sexual Function - Androgens
TRT and Sexual Function - Androgens

Sexual symptoms are the most specific determinants of low 

~ Best Practice & Research Clinical Endocrinology & Metabolism, ScienceDirect

Erectile Dysfunction and Testosterone Deficiency
Erectile Dysfunction and Testosterone Deficiency

A definitive role of testosterone in erectile function has been controversial; however, recent evidence is becoming available which substantiates a key function for this hormone. Testosterone deficiency is associated with a decline in erectile function and testosterone levels are inversely correlate...

~ PubMed

Testosterone and Obesity
Testosterone and Obesity

Testosterone is a key hormone in the pathology of metabolic diseases such as obesity. Low testosterone levels are associated with increased fat mass (particularly central adiposity) and reduced lean mass in males. These morphological features are linked to metabolic dysfunction, and testosterone def...

~ PubMed

TRT and Sexual Function - Current Approach to Treatment
TRT and Sexual Function - Current Approach to Treatment

Androgens are essential for the development of the penis and it is well known that testosterone play a critical role in the physiology of erectile function. From animal studies, testosterone insufficiency disrupts cellular-signaling pathways and induces pathologic alterations in penile tissues leadi...

~ PubMed

Relative Hypogonadism and Metabolic Syndrome in Newly Diagnosed Adult Male Patients with Impaired Glucose Tolerance or Type 2 Diabetes Mellitus
Relative Hypogonadism and Metabolic Syndrome in Newly Diagnosed Adult Male Patients with Impaired Glucose Tolerance or Type 2 Diabetes Mellitus

Sex steroid hormones are known to be important regulators of the lipid and glucose metabolism. Lower levels of testosterone (T) or sex hormone-binding globulin (SHBG) have been reported in men with type 2 diabetes. On the other hand, the relationship between relative hypogonadism and metabolic syndr...

~ PubMed

TRT & Weight Loss for Men with Newly Diagnosed Diabetes
TRT & Weight Loss for Men with Newly Diagnosed Diabetes

Men with the metabolic syndrome (MetS) and type 2 diabetes (T2D) often have low testosterone levels. Elevating low testosterone levels may improve features of the MetS and glycemic control. In a single blind, 52-week randomized clinical trial, the effects of supervised diet and exercise (D&E) with o...

~ PubMed