Alternatives to Testosterone Replacement: Testosterone Restoration
People are asking...
With continued estrogenification of our environment in societal wide decreases in testosterone and sperm count, not everyone is going to necessarily f...
The question really comes down to do you have primary or secondary hypogonadism. If you have primary hypogonadism, you could take all the enclomiphene in the world and it would not adequately raise th... See Full Answer
What do you think of gels, creams, pellets, patches, natesto and other methods of testosterone administration other than injection? Seems to be mixed...
In general, they are less effective than injections. The reason for the mixed opinions is generally because for some people, just a small change is enough of a boost for them and they'd rather not hav... See Full Answer
What is your opinion on exemestane monotherapy to restore testosterone levels of someone with secondary hypogonadism?...
Exemestane can increase testosterone levels by reducing circulating estrogen. Estrogen has a negative feedback loop on the pituitary's production of FSH and LH. So logically, you might be able to incr... See Full Answer
Have a question? Ask us.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
The European Male Aging Study has demonstrated that the hypogonadism of male aging is predominantly secondary. Theoretically with appropriate stimulation from the pituitary, the aging testis should be able to produce eugonadal levels of testosterone. The strategies for the treatment of late onset hypogonadism (LOH) have focused on replacement with exogenous testosterone versus restoration of endogenous production. The purpose of this article is to review existing peer-reviewed literature supporting the concept of restoration of endogenous testosterone in the treatment of LOH.
In view of the EMAS studies, secondary hypogonadism accounts for over 85% of LOH. Ample evidence exists for a deficiency in GTP stimulation with the older men and the ability of the testes to respond to increased GTP production. We currently have several generic medications that accomplish an increase in GTP and normalization of serum testosterone with a favorable side-effect profile. Though shown to be efficacious and well-tolerated in a number of trials, none of the restorative strategies are FDA approved and caution must be advised in their off-label use. Hopefully, future trials will be undertaken to establish a long-term efficacy and safety restorative therapies. Early clinical trials of the compound enclomiphene are encouraging and hopefully will lead to a change in paradigm from TREP to TRES.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650464/
Have a question? Ask us.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
People are asking...
With continued estrogenification of our environment in societal wide decreases in testosterone and sperm count, not everyone is going to necessarily f...
The question really comes down to do you have primary or secondary hypogonadism. If you have primary hypogonadism, you could take all the enclomiphene in the world and it would not adequately raise th... See Full Answer
What do you think of gels, creams, pellets, patches, natesto and other methods of testosterone administration other than injection? Seems to be mixed...
In general, they are less effective than injections. The reason for the mixed opinions is generally because for some people, just a small change is enough of a boost for them and they'd rather not hav... See Full Answer
What is your opinion on exemestane monotherapy to restore testosterone levels of someone with secondary hypogonadism?...
Exemestane can increase testosterone levels by reducing circulating estrogen. Estrogen has a negative feedback loop on the pituitary's production of FSH and LH. So logically, you might be able to incr... See Full Answer
Get $30 off your first month’s order
Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.
Legal Disclaimer
This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.