TRT and Sexual Function - Endocrinological Control
People are asking...
I've been on TRT for 1.5 years and have not been able to figure out why it has caused ED. Estrogen is where it should be. I'm not on excess T. Not on ...
The melanocortin receptor pathway is a relatively newly discovered mechanism for both erectile function and libido. It is entirely separate from traditional hormonal pathways previously thought to be ... See Full Answer
With continued estrogenification of our environment in societal wide decreases in testosterone and sperm count, not everyone is going to necessarily f...
The question really comes down to do you have primary or secondary hypogonadism. If you have primary hypogonadism, you could take all the enclomiphene in the world and it would not adequately raise th... See Full Answer
Does TRT benefit erection quality?...
Yes, generally the three main reasons people start TRT are: Energy/motivation, fat loss issues/muscle loss, and libido/erectile function.... See Full Answer
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Introduction
Several hormones and neurotransmitters orchestrate men’s sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aim
To provide an overview and recommendations regarding endocrinologic control of sexual desire and arousal and erection and their disturbances.
Methods
Medical literature was reviewed by the subcommittee of the International Consultation of Sexual Medicine, followed by extensive internal discussion, and then public presentation and discussion with other experts. The role of pituitary (prolactin, oxytocin, growth hormone, and α-melanocyte-stimulating hormone), thyroid, and testicular hormones was scrutinized and discussed.
Main Outcome Measures
Recommendations were based on grading of evidence-based medical literature, followed by interactive discussion.
Results
Testosterone has a primary role in controlling and synchronizing male sexual desire and arousal, acting at multiple levels. Accordingly, meta-analysis indicates that testosterone therapy for hypogonadal individuals can improve low desire and erectile dysfunction. Hyperprolactinemia is associated with low desire that can be successfully corrected by appropriate treatments. Oxytocin and α-melanocyte-stimulating hormone are important in eliciting sexual arousal; however, use of these peptides, or their analogs, for stimulating sexual arousal is still under investigation. Evaluation and treatment of other endocrine disorders are suggested only in selected cases.
Conclusion
Endocrine abnormalities are common in patients with sexual dysfunction. Their identification and treatment is strongly encouraged in disturbances of sexual desire and arousal.
https://www.sciencedirect.com/science/article/abs/pii/S1743609516000849
Have a question? Ask us.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
People are asking...
I've been on TRT for 1.5 years and have not been able to figure out why it has caused ED. Estrogen is where it should be. I'm not on excess T. Not on ...
The melanocortin receptor pathway is a relatively newly discovered mechanism for both erectile function and libido. It is entirely separate from traditional hormonal pathways previously thought to be ... See Full Answer
With continued estrogenification of our environment in societal wide decreases in testosterone and sperm count, not everyone is going to necessarily f...
The question really comes down to do you have primary or secondary hypogonadism. If you have primary hypogonadism, you could take all the enclomiphene in the world and it would not adequately raise th... See Full Answer
Does TRT benefit erection quality?...
Yes, generally the three main reasons people start TRT are: Energy/motivation, fat loss issues/muscle loss, and libido/erectile function.... See Full Answer
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