Erectile Dysfunction and Testosterone Deficiency
People are asking...
How do you manage bph while on TRT? I’ve considered finasteride but hear very conflicting information about its usage....
Because of the way it works to decrease DHT levels, and because DHT is very important in sexual function, it has a known potential side-effect of erectile dysfunction. Despite this potential side ef... See Full Answer
I've been on TRT for 1.5 years and have not been able to figure out why it has caused ED. Estrogen is where it should be. I'm not on excess T. Not on ...
The melanocortin receptor pathway is a relatively newly discovered mechanism for both erectile function and libido. It is entirely separate from traditional hormonal pathways previously thought to be ... See Full Answer
Do you think that most mental health issues are contra indications for starting TRT? Such as depression and bipolar for example? Or have you seen peop...
For us, we have had a significant number of patients join us with slight anxiety or depression start TRT and find that those mental health issues improved or went away for them. It is likely that it w... See Full Answer
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A definitive role of testosterone in erectile function has been controversial; however, recent evidence is becoming available which substantiates a key function for this hormone. Testosterone deficiency is associated with a decline in erectile function and testosterone levels are inversely correlated with increasing severity of erectile dysfunction. Erectile dysfunction can be caused by multifactorial pathologies. In particular, erectile dysfunction may be the first symptom of cardiovascular disease. Animal studies have demonstrated that castration causes vascular smooth muscle cell atrophy, venous leakage, adipocytes in the subtunical space, loss of elastic fibers and increase in collagen deposition. Testosterone increases the expression of nitric oxide synthase and phosphodiesterase type 5, both principal enzymes involved in the erectile process. Testosterone replacement alone in hypogonadal men can restore erectile function. A significant proportion of men who fail to respond to a PDE5 inhibitor are testosterone deficient. Testosterone replacement therapy can convert over half of these men into phosphodiesterase type 5 responders. It is now recommended that testosterone levels should be assessed in all patients with erectile dysfunction.
https://pubmed.ncbi.nlm.nih.gov/19011292/
Have a question? Ask us.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
People are asking...
How do you manage bph while on TRT? I’ve considered finasteride but hear very conflicting information about its usage....
Because of the way it works to decrease DHT levels, and because DHT is very important in sexual function, it has a known potential side-effect of erectile dysfunction. Despite this potential side ef... See Full Answer
I've been on TRT for 1.5 years and have not been able to figure out why it has caused ED. Estrogen is where it should be. I'm not on excess T. Not on ...
The melanocortin receptor pathway is a relatively newly discovered mechanism for both erectile function and libido. It is entirely separate from traditional hormonal pathways previously thought to be ... See Full Answer
Do you think that most mental health issues are contra indications for starting TRT? Such as depression and bipolar for example? Or have you seen peop...
For us, we have had a significant number of patients join us with slight anxiety or depression start TRT and find that those mental health issues improved or went away for them. It is likely that it w... See Full Answer
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