Cardiovascular Disease, Hypogonadism and ED: Early Detection, Prevention and the Positive Effects of Long-Term TRT
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How long does using trt, or using full cycles take to from a blockage or, worsen a blockage of the heart?...
TRT does not increase risk of heart attack at all. In fact, it seems to reduce the risk TRT has been proven to lower cholesterol Long term TRT has been proven to cause significant reductions in s... See Full Answer
My friend was in the hospital for CHF with mild ejection fraction and no clots. All good markers are good and Ejection fraction is now normal. Can be ...
The science is pretty clear on the fact that low testosterone is a greater risk factor for heart disease and CHF than TRT. The latest research on the matter shows that TRT is cardioprotective and impr... See Full Answer
I see people post on various threads on steroids and how they age substantially in a few years. Does TRT have similar effects or is that more hardcore...
For traditional TRT, aka non-bodybuilding levels of Testosterone, this is almost what we would consider the opposite. Testosterone in men helps to maintain metabolism & low Testosterone often leads to... See Full Answer
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In this prospective longitudinal study of 622 men on TRT: erectile function increased significantly, average weight loss was 23.6 ± 0.6 kg after 8 years, blood glucose readings improved and several patients with diabetes went into remission. Cholesterol levels improved significantly and systolic blood pressure decreased by 33±1 mmHg on average.
Purpose
Erectile dysfunction (ED) is associated with testosterone deficiency and is a symptom of functional hypogonadism. A correlation between ED and cardiovascular disease (CVD) has been recognized, and ED has been proposed as an early marker of CVD. However, the relationship between ED and CVD risk in hypogonadism requires clarification and whether testosterone therapy (TTh) can be a beneficial treatment strategy, but long-term data are limited. This study investigates long-term TTh in men with hypogonadism and ED with a history of CVD.
Methods
Seventy-seven patients with a history of CVD and diagnosed with functional hypogonadism and erectile dysfunction (erectile function domain score <21 on the International Index of Erectile Function questionnaire (IIEF questions 1–5)) were enrolled and TTh effects on anthropometric and metabolic parameters investigated for a maximum duration of 12 years. All men received long-acting injections of testosterone undecanoate at 3-monthly intervals. Eight-year data were analysed. Data collection registry started in November 2004 till January 2015.
Results
In hypogonadal men receiving TTh, IIEF increased by 5.4 (p<0.001). Total weight loss was 23.6 ± 0.6 kg after 8 years. HbA1c had declined by an average of 2.0% (P<0.0001). Total cholesterol levels significantly declined following TTh after only 1 year (P<0.0001), and HDL increased from 1.6±0.5 at baseline to 2±0.5 mmol/L following 8 years of TTh (P<0.0001). SBP decreased from 164±14 at baseline to 133±9 mmHg, signifying a reduction of 33±1 mmHg (P<0.0001).
Conclusion
In hypogonadal men with a history of CVD, TTh improves and preserves erectile function over prolonged periods with concurrent sustained improvements in cardiometabolic risk factors. Measuring ED and testosterone status may serve as an important male health indicator predicting subsequent CVD-related events and mortality and TTh may be an effective add-on treatment in secondary prevention of cardiovascular events in hypogonadal men with a history of CVD.
Have a question? Ask us.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
People are asking...
How long does using trt, or using full cycles take to from a blockage or, worsen a blockage of the heart?...
TRT does not increase risk of heart attack at all. In fact, it seems to reduce the risk TRT has been proven to lower cholesterol Long term TRT has been proven to cause significant reductions in s... See Full Answer
My friend was in the hospital for CHF with mild ejection fraction and no clots. All good markers are good and Ejection fraction is now normal. Can be ...
The science is pretty clear on the fact that low testosterone is a greater risk factor for heart disease and CHF than TRT. The latest research on the matter shows that TRT is cardioprotective and impr... See Full Answer
I see people post on various threads on steroids and how they age substantially in a few years. Does TRT have similar effects or is that more hardcore...
For traditional TRT, aka non-bodybuilding levels of Testosterone, this is almost what we would consider the opposite. Testosterone in men helps to maintain metabolism & low Testosterone often leads to... See Full Answer
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