TRT Stack Spotlight: What Actually Works?

When it comes to testosterone replacement therapy (TRT), many guys discover that just boosting their T levels isn’t the full story. That’s where TRT stacks come in—combining TRT with other treatments or supplements to fine-tune energy, libido, mood, muscle growth, and more.

But which stacks actually work? Which are worth the hype—and which could cause more harm than help?

Let’s break it down.

What Is a “TRT Stack”?

A TRT stack refers to pairing your testosterone therapy with additional compounds like HCG, anastrozole, peptides, or supplements to help balance hormones, protect fertility, or target specific goals like energy, libido, fat loss, or recovery.

Think of it as upgrading your TRT protocol to better match your body’s needs.

Popular TRT Stacks (and What They’re Good For)

TRT + HCG (Human Chorionic Gonadotropin)

Why people stack it:
HCG mimics LH (luteinizing hormone), helping keep the testes active, preserve fertility, and prevent testicular shrinkage.

Pros:

• Maintains natural testosterone production
• Helps preserve sperm count
• May support mood, libido, and testicular size

Cons:

• Must be injected
• Can raise estrogen in some men
• Some find it hard to dose correctly

Best for:
Men who want to maintain fertility, avoid testicular atrophy, or feel “off” on TRT alone.

TRT + Anastrozole (Arimidex)

Why people stack it:
TRT can sometimes raise estrogen levels too high. Anastrozole is an aromatase inhibitor (AI) that reduces estrogen conversion.

Pros:

• May reduce water retention, mood swings, or gynecomastia (man boobs)
• Helps balance the testosterone:estrogen ratio

Cons:

• Overuse can crash estrogen (leading to low libido, joint pain, fatigue)
• Needs careful dosing and labs

Best for:
Men with estrogen-related side effects on TRT (but always under medical guidance!)

TRT + Peptides (like BPC-157, Sermorelin, or Ipamorelin)

Why people stack them:
Peptides are short chains of amino acids that can signal healing, recovery, or hormone production. Some of the most popular peptides for TRT patients include:

• BPC-157: Known for joint and soft tissue healing
• Sermorelin: Stimulates natural growth hormone production
• Ipamorelin: A GH-releasing peptide that may support lean mass and fat loss

Pros:

• Improved recovery and joint support (BPC-157)
• Better sleep, energy, and fat metabolism (Sermorelin, Ipamorelin)
• May enhance skin, digestion, and tissue regeneration

Cons:

• Considered “experimental” by some providers
• Can be expensive
• May require several weeks to feel results

Best for:
Men who want to support recovery, longevity, fat loss, and growth hormone levels—especially those active in fitness or performance.

The Bottom Line: Stacks Aren’t One-Size-Fits-All

The right TRT stack depends on your goals, your labs, and your response to therapy. What boosts one guy’s energy could wreck another’s sleep. That’s why working with a hormone-knowledgeable provider (like the team at AlphaMD) is key.

Real Talk: What’s Worked for You?

We know every guy’s TRT journey is different—and we want to hear from you.

→ What stacks have made the biggest difference in your TRT results?
→ Did HCG help? Did an AI hurt? Are you loving peptides—or skipping them?

Send your story to info@alphamd.org and let us know what’s worked. With your permission, we may feature your (anonymous) journey in a future article or newsletter!