There are zero studies to cite where enclomiphene is used concurrently with TRT. For this reason, its use is still considered experimental. We have seen some men still maintain a measurable LH level ... See Full Answer
The melanocortin receptor pathway is a relatively newly discovered mechanism for both erectile function and libido. It is entirely separate from traditional hormonal pathways previously thought to be ... See Full Answer
Because of the way it works to decrease DHT levels, and because DHT is very important in sexual function, it has a known potential side-effect of erectile dysfunction. Despite this potential side ef... See Full Answer
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
There’s a new conversation happening among men who want to take their hormone optimization to the next level — and it’s all about the stack.
Not a bodybuilding stack.
Not an overhyped supplement stack.
We’re talking about a strategic medical stack that combines:
Together, they’re being used by forward-thinking providers and patients to build a smarter, more personalized approach to men’s health. So, does it work? Is it safe? And who should consider it?
Let’s break it down.
TRT alone can dramatically improve energy, mood, muscle mass, libido, and mental clarity — especially in men with clinically low testosterone.
But some men — especially those who want to stay fertile, preserve testicular function, or support growth hormone levels — may benefit from targeted adjunct therapies.
Enter enclomiphene and sermorelin.
Enclomiphene is a selective estrogen receptor modulator (SERM) — a modern, purified version of clomiphene citrate (Clomid).
While TRT suppresses your natural testosterone production, enclomiphene stimulates your body to make more of its own by increasing LH and FSH.
Think of enclomiphene as a signal booster for your pituitary. TRT gives you T — enclomiphene helps your body keep making it, too.
Sermorelin is a peptide that stimulates your pituitary to release growth hormone (GH).
Unlike synthetic HGH, sermorelin encourages your body to produce its own GH — safely and in a regulated way.
When paired with TRT, sermorelin can help optimize the full hormonal picture — not just testosterone.
Yes — for the right patients, this combination can be a game-changer.
At AlphaMD.org, we’ve seen the "TRT + Enclomiphene + Sermorelin" stack help men:
✅ Stay fertile and maintain natural testicular function
✅ Recover faster and sleep deeper
✅ Improve body composition with more lean mass and less fat
✅ Enhance cognitive sharpness and resilience
✅ Feel more balanced emotionally — and consistently energized
But here's the key: stacking only works when it's personalized.
This isn’t a one-size-fits-all protocol.
But we often explore this stack for men who:
This isn’t about taking more.
It’s about taking exactly what you need — and nothing you don’t.
As with any hormone therapy, there are potential downsides:
⚠️ Enclomiphene can raise estrogen levels if not monitored properly.
⚠️ Sermorelin may cause water retention, headaches, or fatigue in some patients.
⚠️ Combining therapies without clinical guidance can create unpredictable hormone imbalances.
That’s why working with a knowledgeable provider is non-negotiable.
At AlphaMD.org, we don’t guess — we test, track, and adjust to make sure your protocol actually works for your body.
TRT is powerful on its own.
But when thoughtfully paired with enclomiphene and sermorelin, it becomes part of a truly advanced hormone strategy — one that respects your biology, goals, and long-term health.
We call it The New Stack — and for many men, it’s the next level.
We’ll help you find out what you actually need — and nothing more.
👉 Book your consultation with AlphaMD.org today.
No fluff. Just results.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
There are zero studies to cite where enclomiphene is used concurrently with TRT. For this reason, its use is still considered experimental. We have seen some men still maintain a measurable LH level ... See Full Answer
The melanocortin receptor pathway is a relatively newly discovered mechanism for both erectile function and libido. It is entirely separate from traditional hormonal pathways previously thought to be ... See Full Answer
Because of the way it works to decrease DHT levels, and because DHT is very important in sexual function, it has a known potential side-effect of erectile dysfunction. Despite this potential side ef... See Full Answer
Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.
This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.