question from a user
I have a few questions: I’ve been trying to dial in my dose since starting TRT back in Oct ‘24 and making small adjustments every 6-weeks then getting bloodwork to see impact of adjustments. This last time I switched from 45mg every 3.5 days to 26mg every other day and my total test shot up from 625 to 993. Any idea why this would happen given the total amount of test per a week is the same? (My weight did drop 10 lbs from 215 to 205 and I made sure to take the bloodwork in AM before next shot). My DHT bloodwork shows it’s high as it’s 66 ng/dL and the normal range is 12-65 ng/dL. Is this cause for concern (such as potential hair loss).
AlphaMD's Answer
It is known that your average testosterone levels on TRT will be a bit higher with more frequent injections. This is just due to the extended half-life of testosterone cypionate. Losing some weight may have some effect, though testosterone is not dosed based on weight, so we cannot say for sure.
DHT, like estradiol levels, is a very different issue based on the individual. Some men are more estrogen sensitive (their estrogen receptors are more sensitive) and will have high E2 symptoms even at levels that would be considered normal (34-40 pg/mL). Some men have E2 levels of 80 pg/mL and have no symptoms whatsoever. DHT may cause problems if you are genetically predisposed to its effects. If you aren’t, then being above the “normal” range is nothing of concern.
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