Is 1 ml of Testosterone a Week Enough? Understanding Dosage in TRT

Updated on: August 7, 2025

Testosterone Replacement Therapy (TRT) isn’t a one-size-fits-all solution. Whether 1 ml of testosterone per week is enough depends on several critical factors:

Core Considerations

• Concentration matters. 1 ml can contain anywhere from 100 mg to 200 mg of testosterone, based on the medication’s formulation
• Individual goals and physiology differ. Some individuals may respond well to 100 mg/week; others may need closer to 200 mg or adjustments based on lab results, symptom relief, and tolerance
• Medical guidance is essential. The Mayo Clinic notes a common starting dose is 75 mg subcutaneously once per week, with physician supervision for dose refining
• Doctor-led monitoring ensures safety. Adjustments based on blood serum levels and therapeutic response help mitigate side effects and ensure benefits.

Quick Reference: TRT Dosage Snapshot

• Standard weekly range: 100–200 mg (i.e., 1 ml at 100–200 mg/ml)
• Initial, physician‑recommended starting dose (e.g., Mayo Clinic): ~75 mg subcutaneously per week
• Research-based muscle response (Bhasin et al., 2001): Benefits increased with higher doses (125, 300, 600 mg/week) in terms of muscle mass and strength

Why This Matters for You

Opting for 1 ml of testosterone per week can be a practical and effective starting point. Yet, success hinges on:

1. Knowing the concentration of your testosterone preparation.
2. Working with a medical prescriber who orders serum testosterone checks and tailors your regimen.
3. Tweaking dosage based on results and symptoms—not presumptions.

FAQ Section

Q1: Can I simply use 1 ml per week and expect consistent results?
A: Only if you know the exact mg value per ml and receive close follow-up. Without monitoring, you could be underdosing—or risking side effects.

Q2: How do higher doses (above 1 ml/week) compare?
A: Studies like Bhasin et al. indicate that higher doses can lead to greater strength and muscle gains, but must be balanced against heightened risk and are best managed by professionals

Q3: What are early warning signs I might need a dosage tweak?
A: Common adjustments are based on symptoms—fatigue, mood changes, libido—or lab values falling outside mid-normal male testosterone ranges (~400–700 ng/dL), per clinical guidelines

Q4: Are there risks with injection frequency/dose?
A: Yes—risks range from peak‑related side effects to rare but serious events like oil embolisms. Splitting doses or altering frequency may reduce these risks PubMed Central+3en.wikipedia.org+3Mayo Clinic+3.

Q5: Can I keep using 1 ml weekly long-term?
A: You can, if your levels remain within therapeutic range and you're symptomatically stable. Regular lab checks (e.g., every few months) are critical.

Final Thoughts

Using 1 ml per week can be a sound strategy—if the dosage matches your needs and is administered under clinical supervision. By coupling this approach with objective lab data, personalized adjustment, and expert oversight, you’re setting yourself up for both effectiveness and safety.

For deeper learning on TRT dose ranges and guidelines, see the Mayo Clinic’s guidance on injectable testosterone dosing.