Pancreatitis & TRT - Reddit AMA #1, Part 4

Excerpt from our first Reddit AMA podcast video: Can pancreatitis be caused or be related to TRT programs?

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Garrett Soames: Yeah, yeah. So let's see. This next one that we're looking at. Was someone who basically said he was seen in the ER for pancreatitis and he was wondering if that's a side effect of TRT. The it was written by our stupid earth. Our stupider said, Hey there, thanks for doing this. I've been on for about 18 months with minimal side effects and suddenly over New Years, I developed pancreatitis for the first time, Docs at the, ER, couldn't rule out TRT as a cause, but they didn't seem very knowledgeable. I'm waiting for an appointment with my endo that isn't until the end of the month. Is it possible that this is TRT related? so,

Garrett Soames:  Pancreatitis is extremely common. I used to work in the ER for over 11 years. I probably treated thousands of patients with with pancreatitis most commonly probably eight or nine times out of 10 is alcohol related. You know, have this happening, having happened over New Years, you know, again, you got a question. Well, were you partying a lot? The night before, right? Was a little more alcohol than you're used to. So that's always you know, consideration as far as what causes pancreatitis the second, most common cause it's gallstones, they block the biliary duct and then it that bile backs up and you know, swells up the pancreas. um, As far as drug-induced pancreatitis, it is a known entity. There are quite a few drugs that can cause pancreatitis certain blood pressure medicines certain antibiotics.

Garrett Soames:  And the only hormone that is known and proven to cause pancreatitis is actually estrogen. Um, there's no there's no evidence that testosterone causes pancreatitis. I did a PubMed search just to double check and make sure I wasn't, you know, out of tune or or anything. And sure enough all of that PubMed. There was not a single case study or study that proved or even showed that testosterone can cause pancreatitis. So, I think if, if there's no evidence of that, it's, it's pretty clear to say that TRT was not the cause for your pancreatitis.

Garrett Soames:  In you know in med school they they train you to say Never say never never say always so With that in mind knowing estrogen can cause pancreatitis. I guess there's a slight possibility that other sex hormones could cause pancreatitis. But again if if you if testosterone caused your pancreatitis then you are the very first person that has ever caused pancreatitis in and you should probably get be a case study so you can make some money from the journal. but ultimately,

Garrett Soames:  As you mentioned in your question that you were you were on the TRT for 18 months, prior to your pancreatitis. So typically in drug-induced pancreatitis, it's usually occurs within the first few doses. And so the fact that you tell me you've been doing trt for 18 months, in my mind, completely rules it out as the cause. So, there are idiopathic cases of pancreatitis. Meaning, we don't know. Idiopathic is literally the medical word for You know, so you could have had an idiopathic case, I don't know. But Yeah, don't blame your TRT. You're in Endo will probably tell you the same. But yeah, I think it's safe for you to get back on your your regular dose.