question from a user
In your experience, does 3x/week really give any significant advantage compared to 2x/week? I'm about to start trt again after being on clomid for few years for fertility, and back when I was on trt I used to get insane migraines. That's why I'm planning on pinning 2x/week instead of the 1x/week protocol I used to follow.
AlphaMD's Answer
More frequent injections results in less “overflow effect”. Basically, it lowers the peaks, causing less conversion to estradiol (the typical hormonal cause for migraine). Changing from 2 shots to 3 shots a week lowers E2 by an average of 20%.
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