question from a user
Does hcg dramatically increase e2 or is it fairly negligible? We see a lot of people claim it does on reddit, but I thought it's the higher than needed testosterone that's aromatising with infrequent injection rather than the hcg stimulating significant e2.
AlphaMD's Answer
hCG does seem to aromatize a bit more than exogenous testosterone. This is because aromatase is found not just in adipose tissue, but also within the Leydig cells in the testicles. Since exogenous testosterone cannot make its way into the testicles, the aromatase naturally found in the Leydig cells does not contribute to total estradiol levels until hCG is added.
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