Can you pair low-dose enclomiphene with testosterone for hypogonadism treatment? Would it overall help increase testosterone levels? I recently switched from enclomiphene 25mg to 12.5mg, wasn't loving the side effects of nausea, but I did feel it working. I started on Test-E 200mg every 2 weeks (I know that I need to probably do smaller doses every week), but I am curious if I reduce my enclomiphene dose to 6.25 that it could have some added benefit?

AlphaMD's Answer

This may not be the answer you like, but it may be best not to combine them.

Here's the reasoning:

Clomid & Enclomiphene can both inhibit IGF-1 in the body, which is responsible for a lot of the physical & muscle/protein generation benefits most people associate with TRT. When taken alone Enclomiphene may raise your baseline production of Testosterone to a point that the benefits overshadow this, but when on Testosterone injections that's where you're going to be getting most of your Testosterone from so there's no reason to lower IGF-1 in that case.

If you're looking for more benefits because your regimen feels lacking, the first thing to explore with your provider would be increasing the frequency of your injections. 2 weeks between injections with that ester is going to leave you feeling pretty low that second week after the spike in the first. Ideally, the provider overseeing your care can adjust your schedule to your normal weekly dose divided in half. So rather than 200mg once every 2 weeks, 50mg twice each week would be the same dose but your body would love you a lot more for doing it that way & you should feel a lot more evened out.

Once you do that, and if you still feel lacking, 100mg a week can certainly be raised a bit without issue & should be discussed with your provider.