question from a user
A lot of people on here say AI’s are unsafe and you shouldn’t be on them but plenty of people need it (including me) What’s the max safe dose someone should consider?
AlphaMD's Answer
The typical dosing for AIs is perfectly safe to work with. You will run into issues at large doses like 7mg Anastrozole a week, but that's wildly way too high for it's purpose in TRT. All of the guys stating that anastrozole is unsafe are quoting from studies done in women with hormone sensitive breast cancer; where the goal of the therapy is to crash estrogen to zero. The goal of every single study done with anastrozole was to crush estrogen to zero; to slow the growth of cancer in these unfortunate women. Of course they got osteoporosis and terrible lipids and felt miserable. They had no estrogen to speak of. I challenge you to find a study TRT in men that show any long-term detriment to health. You won’t find one.
Still, you should try not to use an AI if it can be avoided. Often it is better to adjust dose and/or injection frequency to control romanization. That being said, it is perfectly safe in most men to be using 0.5mg-2mg a week as an average value.
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